Changes in cell surface markers in human small bowel transplantation with FK 506.
نویسندگان
چکیده
منابع مشابه
Intravenous, oral pharmacokinetics, and oral dosing of FK 506 in small bowel transplant patients.
FK 506 is a new macrolide with potent immunosuppressive activity. Use of this drug is associated with reduced incidence of rejection following liver. kidney. and heart transplantation. 1-4 Recently, FK 506 has been shown to be effective in small bowel transplantation. S It is known that FK 506 absorption is not influenced by the presence or absence of bile.6--8 The aims of this study are to: (\...
متن کاملSuccessful orthotopic small bowel transplantation with short-term FK 506 immunosuppressive therapy.
A LTHOUGH small bowel transplantation is the physiologic treatment of the short bowel syndrome, Its clinical implementation awaits development of immunosuppressive regimens that ensure satisfactory control of graft rejection. Agents such as Cy A and corticosteroids are useful for transplantation of most other vascularized organ allografts. However, rejection of the transplanted small intestine ...
متن کاملUnusual Case Report of Thrombotic Microangiopathy of the Small Bowel Following Liver Transplantation, a Possible Immunosuppressant-Induced Disease with Histological and Ultrastructural Findings
Cyclosporin-A (CsA) and tacrolimus (FK-506) are immunomodulating agents used to prevent rejection in organ transplantation. They are both associated with several side effects, including nephrotoxicity and severe hypertension due to vascular injury, which often appears as a microvascular occlusive disorder (thrombotic microangiopathy, TMA). We report the first case of a microvascular occlusive d...
متن کاملSmall bowel and liver/small bowel transplantation in children.
A clinical trial of intestinal transplantation was initiated at the University of Pittsburgh in May 1990. Eleven children received either a combined liver/small bowel graft (n = 8) or an isolated small bowel graft (n = 3). Induction as well as maintenance immunosuppression was with FK-506 and steroids. Four patients were male, and seven were female; the age range was 6 months to 10.2 years. The...
متن کاملComparison of short-term immunosuppressive therapy with cyclosporine and FK 506 in small-bowel transplantation.
SINCE small-bowel transplantation was first described experimentally in the Iale 19505, control of graft rejection has been recognized as the primary obstacle to its successful clinical implementation. Early experimental and clinical studies demonstrated that immunosuppressive regimens based upon azathioprine, antilymphocyte globulin, and corticosteroids were not sufficient to ensure longterm r...
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ورودعنوان ژورنال:
- Transplantation proceedings
دوره 24 3 شماره
صفحات -
تاریخ انتشار 1992